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Business Plan Laundry Essay Sample. The mission of the Davidson College Laundry is to provide laundry services to addiction, students, college departments, and of a Essay, private individuals. Addiction To Tv. By doing so in family patterns, a convenient, timely, personalized and addiction to tv, financially responsible manner, the examples foods, College Laundry enables students to spend more time in to tv, academic and extra-curricular pursuits and effectively supports departmental activity. Services include the care and handling of personal clothing, bed linens, dry cleaning, and in media, catering linens. Core Values. Integrity Every member of our organization behaves in to tv, an ethical manner. We will do the right things for the right reasons. The Guidance Of A Government. Customer Service We will act in the best interest of our customers, providing the highest level of to tv customer satisfaction through service, quality and responsiveness. Examples. Collaboration Through collaborative efforts we will foster opportunities for individual and organizational growth. We will treat all employees with dignity and respect. Vision Statement. The Lula Bell Houston Laundry continues to provide high quality service to its customers by implementing services and programs that provide greater convenience to their lives. The College Laundry has provided broader services and addiction, greater accessibility with enhancements like the Essay on Wild Style, directed by Charlie Ahearn, after hours laundry drop-off, a larger, more accessible self-service washroom with amenities allowing students to to tv, study or relax while waiting on their laundry.

Simultaneously the of women in media, College Laundry has grown its cash business significantly through improved marketing and to tv, promotions efforts. S.W.O.T. Analysis. Provide great laundry service. Impressive pricing for services. Quality Dry cleaning. Getting good feedback from family patterns, Customers (Gratitude from addiction to tv, customers) Bringing money to the college. The Guidance Of A Government Essay Examples. Communication with other department. Addiction. Home like atmosphere. Is Social Control. Low exposure to addiction, the outside market. Hours of operation. An adequate amount of Essay Public Policy staff. Not having enough equipment (washer / Dryers and Folding table space) Trying to keep up with the Joneses when there is day to addiction to tv, day work to get done. Health issues keeping people out of work. What Is Social Control Theory. Taking on too many different jobs, being too diverse. Becoming so care to the person that we forget about the addiction, larger group. Air Conditioning Now! Beauty of the campus. Foods. Location of the Laundry. Sense of job security. Growing Student enrollment. Addiction To Tv. Laundry closed at portrayal of women, down times lose $ Not having the to tv, money or approval to make the The Guidance Government Essay examples, necessary changes. To Tv. Our own fears of getting so big/diverse that we lose what weve had for Essay on Why Public, so long our sense of family. Addiction. The current self-op wash/dry room for student use is very small and students clamor for more such space. The residence hall satellite laundry rooms run the gamut it terms of Public size of space, condition of equipment, and addiction to tv, cleanliness and family patterns, represent a headache administratively from both the addiction, Residence Life Office and significance panama, the Physical Plant. Addiction. Keeping up with volume increases on family patterns fixed revenue is a budgetary challenge, particularly in the area of to tv labor, our single largest expense item. Cash customers are not cultivated from a marketing or promotional standpoint and represent opportunities for in media, new dollars. Addiction. Should an expanded self-op program be implemented, current responsibilities and roles at the Laundry do not include its management. Increase revenue from cash business by Style, directed by Charlie Ahearn developing creative marketing strategies that promote non-student wash-dry-fold business and dry cleaning business from addiction to tv, all customers. Utilize web in family patterns, particular. Develop a business plan for the establishment of an addiction, expanded self-service washroom option within the footprint of the current Laundry facility. Use plan to gain approval and funding for the project. Advocate for additional work-study students in family patterns, our labor force to control labor expenses as volume of work increases.

Xpress Laundry Service Business Plan. Addiction To Tv. 1. Is Social Theory. Executive Summary. Xpress Laundry Service is to tv a laundry service designed to save Xavier University students the The Guidance Government examples, one commodity that they can never get more of: time. The average student wastes an addiction to tv, average of of gm foods 1 ? hours in the laundry room either weekly or bi-weekly. Addiction. This unproductive use of clock time has created a strong demand among Xavier resident students for a company to take this burden of addiction to tv endlessly washing and folding clothes off of their hands. Xpress Laundry Service seeks to meet this demand by providing a much needed high quality service to strategy, these students at a fair and always low price. To Tv. 2. Company Description. Xpress Laundry Service is bowman's strategy a full service laundry service designed with the college students budget in mind.

Basically, Xpress picks up the students laundry from addiction to tv, their residence hall, washes and folds the of a Essay, laundry using only Tide premium detergents, and drops the laundry off within 48 hours. This service is addiction provided at the low price of just $8 per on Wild Style, directed by Charlie Ahearn wash which is addiction to tv defined by The Guidance Government the amount of addiction laundry that the foods, customer can fit into an Xpress Laundry Bag (about 25lbs.) Currently Xpress clientele is continuing to grow each week. This growth is due mostly to Xpress cheap and addiction to tv, aggressive marketing during the past eight weeks. 3. The Guidance Of A Government. Market Analysis. Addiction To Tv. The demand for Xpress service at Xavier is great. To determine the Essay on Wild Style, directed Ahearn, actual demand for the service a market research survey was conducted in addiction to tv, the middle of panama December 2005. Addiction. The survey was taken of is social theory 102 respondents in Brockman Hall which represents about to tv 30% of the on Wild, dorms total population. In the survey 76% of addiction to tv respondents said that they would be interesting in examples foods, using the laundry service while 68% responded that they would be interested in purchasing a laundry plan.

Further 80% reported that they personally do their laundry in the laundry room at Brockman and on to tv a scale of 1-10 65% rated Brockmans laundry facilities between 5 and portrayal in media, 7. To Tv. Clearly these statistics show that Xavier students have an explicit interest in using such a service. Continually, the Essay on Why, survey was only conducted in to tv, Brockman Hall because Brockman is serving as a test market this semester. By starting the what is social control, service only in Brockman, Xpress will better be able to tailor its services to the entire Xavier campus in the fall of 2006 after working out any possible problems. Also, Brockman students serve as an addiction, investment for Essay on Why Public Policy, the company as anywhere from 75% to 85% of the addiction to tv, residents will live on campus next year whereas many students living in what is social, other dorms will move off-campus in addiction to tv, the fall. For this reason the family patterns, majority of the addiction, marketing budget has been directed at Brockman residents. 4. Family Patterns. Marketing Plan and addiction to tv, Previous Marketing. Xpress has been and will continue to use cheap and extremely effective marketing tactics. To this point in time, three marketing promotional days have been conducted in Brockman. 1. First a table was set up in Essay Style, by Charlie Ahearn, the lobby where we passed out donuts in addiction, the morning along with our Xpress business cards. Bowman's. This proved extremely effective as we found that many students instinctively put the addiction to tv, cards in Government, their pockets, many waving them to addiction to tv, us as they passed by our table for strategy, the second time.

2. Next, on Valentines Day we passed out to tv, flyers with heart-shaped Valentines Day lollypops taped to examples foods, them. The flyers had a brief description of the service and to tv, had an Xpress contest number individually printed on significance panama each one. Addiction. The flyer instructed the students to visit our website to Government examples, see if their contest number was a winning number. Prizes for the event included a $25 Itunes gift card and two prizes for addiction to tv, two weeks of bowman's strategy clock free laundry service. This also proved extremely effective as we saw traffic to our website (www.XpressLaundryService.com) increase by 82 hits that week. The main goal of the addiction, activity had the directed Ahearn, Rule of addiction to tv 9 in mind which states that a potential customer has to see, hear, or speak the company name approximately 9 times before they will become an actually customer. In Media. 3. Addiction. For our third event a professionally made Xpress Laundry Service banner was purchased and clock, displayed at our table in the lobby of Brockman and we passed out our custom made Xpress Laundry Service pens which list our phone number, website address, and pickup and to tv, drop-off times. Essay. Moreover, I received permission from Dan Yaeger to display triangular flyers on the tables in addiction to tv, the Cintas cafeteria.

New flyers are placed on Essay Style, the tables each week and addiction to tv, have generated some 25 phone calls and significance of the panama, 7 new customers. The flyers give general information about the service, provide special promotion information, and answer frequently asked questions. Xpress marketing future has also been carefully planned. First, a $150 investment will allow Xpress to put flyers in each one of the 800 Manresa folders for incoming students. Addiction. Secondly, a $250 investment will allow Xpress to have a physical presence during move-in day which again draws the 800 new students but much more importantly, over The Guidance of a Government Essay 1100 parents and addiction to tv, family members. Bowman's Clock. During move-in day laundry plans can be sold and addiction to tv, the business can be further promoted. Family Patterns. As college students are very habitual, move-in day will be crucial to future success by to tv hooking the students from the beginning of their college careers. Cafeteria flyer promotions will also continue weekly and family patterns, during the first four weeks of the fall of 2006 promotional days will be held in the lobbies of addiction to tv Brockman, Kuhlman, Buenger, and Husman Halls with two promotions being conducted per on Wild directed week. Continual experience in marketing coupled with hard work will undoubtedly lead to future success for Xpress Laundry Service. 5. To Tv. Operations Plan. Xpress operations have been carefully planned and the previous eight weeks have allowed many problems to be addressed and examples of gm, taken care of. Addiction To Tv. First, Xpress will wash all of of women in media its laundry at X. While planning the addiction, service many possibilities for washing the laundry have been considered. The Guidance Of A Government Essay. One possible idea was to act as middle man as many college laundry services around the addiction, country do, charging $1.20 per pound and paying another service $1.00 per bowman's strategy pound to to tv, do the bowman's strategy clock, laundry for them.

This idea was dismissed after we discovered that the average load of laundry is at least 15lbs. which would put the customers bill at nearly $20, essentially pricing Xpress out to tv, of the market. Instead it will be more profitable for Essay on Why, Xpress to addiction, adopt a lower price, higher volume business model that also allows for greater profit margins. Control Theory. This is achieved by addiction doing the laundry ourselves rather than outsourcing the work. Clock. The actual operations will run as follows. Addiction To Tv. 1. Essay Directed By Charlie. First, laundry will be picked up from the addiction, students on Monday, Tuesday, or Wednesday between the of gm, hours of 2:30 and addiction to tv, 6:00pm.

During those hours Xpress will be on call for pickup. Orders can be placed via telephone or by using the on Why, online pickup page on our website. Addiction. 2. Next the laundry will be washed and examples foods, folded using only addiction Tide premium detergents which allows us to family patterns, market the addiction to tv, service as a premium service. 3. Also, using brand name detergents only increases our costs by about 10 cents per load and significance canal, actually provides better results as evident in Consumer Reports and through personal experience. 4. The laundry will be put into the machines at 15 minute intervals which will allow adequate time for folding laundry (laundry that sits dormant in to tv, a dryer tends to is social theory, wrinkle horribly). 5. To ensure continued quality Xpress uses a 10 Step Care Process that states that pockets will be checked for addiction to tv, pens, clothes will be separated between whites and control theory, darks, etc. After the addiction to tv, laundry is removed from the machines it will be folded and placed back in The Guidance Government Essay examples, the Xpress Laundry Bags horizontally. (The nylon bags measure 26?14 and to tv, hold approximately 25lbs of strategy laundry. On the to tv, bags Xpress Laundry Service is printed along with our phone number, website address, and pickup and Essay, drop-off times.

They are also equipped with a drawstring to ensure that no loose garments like socks ever fall out addiction to tv, of the bags by accident.) 6. Next the clean clothes will be delivered to bowman's clock, the students at a time specified at the time of pickup 48 hours after their laundry is picked up. To Tv. 7. Essay On Why Public Policy. Students are also required to sign the Xpress Laundry Service Terms of Usage agreement which can be found on our website before their first laundry pickup. The terms give liability restrictions for Xpress and addiction, were carefully drafted with the help of family patterns a lawyer who is addiction to tv a family friend. Strategy. Also, Tide Coldwater will be used on all laundry washes as well as Oxiclean. To Tv. Bounce fabric softeners will be used during the dryer cycles and Shout stain remover will be used as needed. 6. Financial Plan. Currently Xpress thrives on a roughly X% profit margin at our price of $8.

Recently, profit margins have increased by Essay Ahearn using Tide Coldwater which saves 40 cents per wash as white clothes can now be washed in cheaper cold water rather than warm. Below is our cost function: Cold Water Cycle for addiction, Whites: $X. Cold Water Cycle for bowman's clock, Colors: $X. Tide for to tv, whites: $X. Of A Government. Tide for colors: $X. Oxiclean for addiction to tv, whites $X. Oxiclean for colors $X.

Bounce fabric softener $X. By generating high enough volume Xpress will easily be able to pay for the labor required to do the laundry while maintaining a healthy margin. The cost function of of women in media labor is such that a constantly busy worker will generate the most profits for addiction, the company while a worker that has less work to do possibly due to a small amount of orders for the day will be less productive. Portrayal Of Women In Media. For this reason high volume is essential. To Tv. To explain the labor function, please consider the theory, following hypothetical situation. To Tv. Xpress has established that one person can comfortably launder 5 orders per hour.

Over 4 hours the total number of orders would be 20 which would bring in $160 of significance of the revenue (20 orders X $8 per addiction to tv order). $80 or approximately X% would represent our fixed cost leaving $X of profit. At $X per hour the worker would be paid $X while Xpress would profit the of a examples, other $X. Xavier students are perfect for addiction to tv, this job as many dont need steady income and family patterns, many would also like to earn extra money for to tv, the weekend. Flexible scheduling could be arranged and a call list could be established. This way, if Xpress was particularly busy we could call on 3 or 4 of the already trained employees on our list and if some werent available we could move down the Essay on Why Public, list until the desired number of workers was reached This relatively low margin (for the industry) will prove the best strategic move for addiction, Xpress by allowing for higher volume. Other laundry services such as Commodore Laundry at Vanderbilt University charge $19.99 for family patterns, a single laundry pickup and over to tv $18 per pickup after a customer signs onto family patterns, their semester laundry plan.

However, while they make more money per load it costs them about 17 marketing dollars to get a new customer compared to to tv, the $5 that Xpress spends to The Guidance Government examples, get a new customer. To Tv. (This information was derived from the owner during a telephone conversation about Commodore Laundrys operations.) 7. Conclusion. Xpress Laundry Service is an up and coming company with a future that will be supported by the great demand for an on-campus laundry service among Xavier University resident students. Through aggressive marketing Xpress has been able to continue to grow its client base week after week without falter. Xpress carefully planned operations will allow for of the canal, terrific growth in the future and continue to evolve as the experimental semester continues. In conclusion, through strategic marketing and attention to detail and to tv, quality Xpress will be able to on Wild Style,, achieve success unmatched by addiction any other student run company at Xavier.

Is this the family patterns, perfect essay for addiction to tv, you? Save time and order Business Plan Laundry. Essay On Wild Style, By Charlie Ahearn. essay editing for only $13.9 per page. Top grades and quality guaranteed! Relevant essay suggestions for Business Plan Laundry. Executive Summary In today#8217;s society, there are increasing numbers of addiction Sydney-siders who spend many hours a day at work, or have children and family patterns, families to look after, or both. To Tv. Shiners#8217;#8230; ?Business Plan for the WRSX Group. Panama. Business Plan for the WRSX Group Participant name: 1. Addiction. Executive Summary (Complete this section of your plan last. Go straight to bowman's strategy, Section 2 of addiction to tv this plan. Return to by Charlie, the Executive#8230; ?Opening a restaurant business plan. Opening a restaurant is addiction going to canal, take a lot of work, but with perseverance, you can enjoy the fruits of your labor come opening day and addiction to tv, when you start making#8230; Business plan evaluation.

Adorable Pet Photography (APP) is a sole proprietorship company that promises to Essay Public, capture memorable pet pictures for their clients. I have chosen APP from the Business Plan Pro softwares sample#8230; Business Model and Strategic Plan. Addiction. The balance scorecard is portrayal of women another tool that goes along the same lines as the to tv, strength, weakness, opportunity, threat, and examples, trend or commonly known as SWOTT. The information in this document#8230; Business Plan of a Bakery.

Honey Coffee and Bakery is a start-up coffee and bakery retail establishment located in jos. HCB expects to addiction to tv, catch the strategy, interest of a regular loyal customer base with its broad#8230;

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Ketogenic diet does not beat chemo for almost all cancers One of the difficult things about addiction to tv, science-based medicine is determining what is and isnt quackery. While it is quite obvious that modalities such as homeopathy, acupuncture, reflexology, craniosacral therapy, Hulda Clarks zapper, the Gerson therapy and Gonzalez protocol for cancer, and reiki (not to mention every other energy healing therapy) are the strategy, rankest quackery, there are lots of treatments that are harder to addiction, classify. Much of the time, these treatments that seemingly fall into a gray area are treatments that have shown promise in animals but have never been tested rigorously in humans or are based on scientific principles that sound reasonable but, again, have never been tested rigorously in humans. (Are you sensing a pattern here yet?) Often these therapies are promoted by true believers whose enthusiasm greatly outstrips the evidence base for their preferred treatment. Canal. Lately, Ive been seeing just such a therapy being promoted around the usual social media sources, such as Facebook, Twitter, and the like.

Ive been meaning to write about it for a bit, but, as is so often the case with my Dug the Dog naturesquirrel!other topics caught my attention. Im referring to a diet called the ketogenic diet, and an article thats been making the rounds since last week entitled Ketogenic diet beats chemo for addiction, almost all cancers, says Dr. Thomas Seyfried. Of course, when I see a claim such as that, my first reaction is, Show me the evidence. My second reaction is, Who is Essay, this guy? Well, Dr. Seyfried is a professor of biology at addiction to tv, Boston College, whos pretty well published. Hes also working in a field that has gained new respectability over Essay on Why the last five to ten years, namely cancer metabolism, mainly thanks to to tv, a rediscovery of what Otto Warburg discovered over 80 years ago.

What Warburg discovered was that many tumors rely on glycolysis for their energy even in environments with adequate oxygen for oxidative phosphorylation, which generates the bulk of the theory, chemical energy used by cells. I described this phenomenon in more detail in a post I did four years ago about a drug that looks as though its anticancer properties come from its ability to addiction, reverse the of women in media, Warburg effect. What not to do if you want your hypothesis to be taken seriously. So on addiction the surface, Dr. Seyfrieds argument that cancer is primarily a metabolic disease (an argument Ill look at canal, in more depth shortly) is well within the bounds of to tv, current oncologic science. Indeed, a few years ago it was all the rage, and I remember attending several sessions and lectures on the Warburg effect and what theory, cancer at the AACR meetings three or four years ago, although, oddly enough, I dont recall as many the to tv, last couple of years.

In any event, if thats all I looked at, I probably would have shrugged my shoulders and moved on, as in, Nothing to see here. But there are quite a few red flags. The first red flag is a claim that a ketogenic diet can treat cancer better than chemotherapy. The second, even bigger, red flag is on Dr. Seyfrieds Boston College web page: In addition, Dr.

Seyfried has worked with noted alternative health advocate Dr. Mercola to provide a thought-provoking discussion on the benefits of a ketogenic diet. Dr. Mercola provides a thorough synopsis of the family patterns, talk on his website, and also includes the original audio recording of their conversation. Uber -quack Dr. To Tv. Mercola?

Oh, dear. His evident pride at having been interviewed by Dr. Mercola does not reflect well on Dr. Seyfrieds critical thinking skills and knowledge of medicine. Dr. Mercola sells quackery. He has promoted antivaccine views, breast cancer pseudoscience, and the rankest cancer quackery, such as that of Tullio Simoncini, who believes that all cancer is a fungus and Government Essay, that baking soda is the to tv, way to treat it, and the Gerson therapy, which involves massive doses of supplements and, of significance panama canal, course, twice-a-day coffee enemas. Seriously, this is not the sort of person a legitimate scientist wants to associate himself witheverif he wants to be taken seriously. To Tv. I can see a naive researcher making a mistake and, not realizing who Dr. Mercola is, agreeing to an interview, but thats the sort of thing that a reputable scientist would do his best to disavow and distance himself from. Neither is the American College for Advancement in Medicine (ACAM), which bills itself as the voice of integrative medicine, where hes given a major talk, the sort of organization a legitimate scientist wants to is social control theory, associate himself with if he wants to be taken seriously.

Dont believe me? Just peruse the ACAM website, where you will find lots of chelation therapy, including a program to certify in chelation therapy and addiction to tv, detoxification, as well as other quackery. Theres a good reason that ACAM has appeared in many SBM posts throughout the years, and not in what, a favorable light. I emphasize again, this is addiction, not an organization with which a scientist who wishes to be taken seriously by oncologists associates himself. Also, if a scientist wishes to be taken seriously, he shouldnt say things like this: The low-carb, high-fat ketogenic diet can replace chemotherapy and radiation for even the The Guidance Government Essay, deadliest of addiction, cancers, said Dr. Essay On Why Policy. Thomas Seyfried, a leading cancer researcher and to tv, professor at The Guidance Essay examples, Boston College. In an exclusive interview, Dr. Seyfried discussed why the ketogenic diet has not been embraced by the medical community to treat cancer despite its proven track record both clinically and anecdotally. The reason why the ketogenic diet is not being prescribed to treat cancer is purely economical, said Dr. Seyfried, author of Cancer as a Metabolic Disease. Cancer is big business.

There are more people making a living off cancer than there are dying of it. And dont associate yourself with Ralph Moss, the number one promoter of to tv, laetrile quackery and Essay, make easily refuted claims such as the addiction to tv, claim that chemo and radiation do not cure cancer or extend life, although cancer physicians often make this claim and that radiation often does more harm than good to the patient. Given that all Dr. Seyfried has is portrayal, a couple of case studies as clinical support for addiction, his treatment (see below) and I can produce reams of studies over panama nearly 50 years demonstrating that chemotherapy can cure specific cancers and addiction, prolong life when used appropriately, the 2% gambit notwithstanding, its not a winning proposition, and it sure doesnt help your credibility to control, use the language of cancer quacks to promote your idea. So, what, exactly is Dr. Seyfrieds hypothesis? Red flags or no red flags, it is, of course, possible that Dr. Seyfried is on to something and has let his enthusiasm overwhelm his judgment with respect to whom he associates with and the sorts of statements he makes, many of which sound as though they could have come from Stanislaw Burzynski, Ralph Moss, or Joe Mercola. To Tv. In actuality, he isnt totally wrong, but he isnt totally right, either. As is typical of someone without a medical background, in particular an oncology background, he is, basically, putting the cart before the family patterns, horse, as you will see. In his talk, Dr. Seyfried begins with what he refers to as a provocative question: Is cancer a genetic or metabolic disease?

Actually, whether he realizes it or not, his question is not quite as provocative as he thinks it is, nor is the answer anywhere near as clear-cut as he thinks it is or as he characterizes oncologists and to tv, cancer researchers as thinking it is. Ill tell you what I think the answer to significance, the question is after Ive discussed Dr. Addiction To Tv. Seyfrieds hypothesis. In the of women in media, meantime, not surprisingly, his answer is that cancer is a metabolic disease, while everyone elses answeraccording to him, at leastis that it is a genetic disease, making him the brave maverick doctor, who says things like: The current view now, without any question, is that cancer is a genetic disease. To Tv. If you go on the National Cancer Institute website or you read any of the major articles published in Nature and Science , often the family patterns, articles will start with, Cancer is a genetic disease. I think that this has become dogma. Except that it really isnt, at least not anymore. Addiction To Tv. If you do a Pubmed search on targeting cancer metabolism, which is bowman's strategy clock, what Dr.

Seyfried is talking about, youll find over to tv 22,000 articles, with over 3,000 in 2013 alone, with a sharply increasing curve since 2000 that only now appears to be leveling off. A search on cancer metabolism brings up 369,000 references, with 28,000 in 2013 alone. Essay On Why Public Policy. Cancer metabolism is an incredibly important topic in cancer research and addiction to tv, has been for several years now, and The Guidance Government Essay, finding means of targeting the to tv, common metabolic abnormalities exhibited by cancer cells is currently a hot area of research. From my perspective, Dr. Seyfried is exaggerating how hostile the portrayal in media, cancer research community is towards metabolism as an to tv, important, possibly critical, driver of cancer, although, to portrayal of women, be fair, one prominent cancer researcher, Robert Weinberg, has been very skeptical. To me, Seyfried just appears unhappy that genetics is currently thoughtfor good reasons, I might addto be the addiction to tv, primary driver of most cancers.

Note that I intentionally used such phrasing, because Dr. What Control. Seyfried, in my readings, appears all too often to speak of cancer as if it were a monolithic single disease. As Ive pointed out many times before, its not. Indeed, only approximately 60-90% of cancers demonstrate the Warburg effect. There are three components to to tv, glucose metabolism: glycolysis, which feeds the Krebs citric acid cycle, which in turn feeds oxidative phosphorylation. I show them below in simplified illustrations: The issue with the Warburg effect is portrayal, that it leads to addiction to tv, a shift in metabolism that favors glycolysis. As a result of this shift, tumor cells tend to use a lot more glucose than normal cells because glycolysis is much less efficient at family patterns, converting glucose into addiction to tv, ATP molecules used for cellular energy than oxidative phosphorylation.

One reason that this is thought to provide a growth advantage to cancer cells is because oxidative phosphorylation requires oxygen while glycolysis does not and cancers frequently outgrow their blood supply such that they often live and family patterns, grow in tissue spaces where there is addiction to tv, not much oxygen. In any case, the is social control theory, avidity of cancer cells for addiction, glucose has been known a long time and bowman's strategy, is the basis for positron emission tomography (PET) scanning, where a radiolabeled derivative of glucose is the addiction, most commonly used tracer for exactly that reason: Tumor cells take it up much more avidly than do normal cells, leading to Essay Public, ugly black blobs (old-fashioned PET scans alone) or pretty bright blobs (PET-CT) where there are tumor masses in the scans. The idea behind ketogenic diets is very simple. If glucose is the primary fuel for cancer, then lower carbohydrate intake and replace carbohydrates with other sources of fuel, such as fats, in order to push the addiction, bodys metabolism into ketosis. It actually turns out that ketogenic diets are probably useful in The Guidance examples, the treatment of to tv, intractable epileptic seizures in children. Unfortunately, their mechanism of action in preventing seizures is unclear, although four potential mechanisms, including carbohydrate reduction, activation of Policy, ATP-sensitive potassium channels by mitochondrial metabolism, inhibition of the mammalian target of rapamycin (mTOR) pathway, or inhibition of glutamatergic synaptic transmission (glutamate as a neurotransmitter), have been proposed.

Interestingly, the mTOR pathway is an important signaling pathway in many cancers that couples energy and nutrient abundance to the execution of to tv, cell growth and division, owing to the ability of of the, TOR protein kinase to simultaneously sense energy, nutrients and stress and growth factors. Its a commonly overactive signaling pathway in cancer. Its also interesting that the cancers used to produce the basic science cited by Dr. To Tv. Seyfried are virtually all brain cancers and that virtually all the evidence comes from rodent tumor models. Government Essay Examples. For one thing, if there is a tumor type that exhibits the Warburg effect and to tv, a high degree of metabolic derangement, its brain tumors. Its no coincidence that dichloroacetate was first tested in bowman's, brain tumors. In this study, VM/Dk mice were used, and a mouse histiocytoma cell line resembling human glioblastoma multiforme with macrophage/microglial properties derived from to tv that same mouse strain (VM-M3) was implanted subcutaneously. This cell line has the of a Government Essay examples, property of metastasizing quickly and addiction to tv, widely when implanted under the skin and allowed to grow, which actually makes it not very much like brain tumors, which seldom metastasize and usually kill through local invasion and is social control theory, taking up increasing volume in the closed space of the skull, something the brain most definitely does not like. To Tv. The results showed that a ketogenic diet increased mean survival time by over 56%, while a combination of a ketogenic diet and hyperbaric oxygen therapy (HBOT) increased survival time 78%.

The result is interesting, but it is a mouse tumor model, not a human tumor model, and what is social, that makes its applicability to addiction to tv, humans tenuous, particularly given the significance panama, nature of the murine tumor, but probably worth investigating further. Another mouse study cited by addiction to tv Seyfried is one in bowman's clock, which dietary restriction was reported to promote vessel maturation in a mouse astrocytoma model. Addiction. Given that tumor angiogenesis is in media, one of addiction, my scientific interests and I have a fair number of publications on family patterns the topic, I was interested. Unfortunately, I ended up being disappointed. This was another syngeneic model (i.e., a mouse tumor implanted in mice of the same strain from to tv which the tumor was isolated as a cell line, like the one discussed above). Although it showed increased tumor vessel maturation (which is one mechanism by which inhibitors of angiogenesis work), I wasnt quite convinced, because there was a distinct lack of on Why Policy, quantification of the phenomenon, and the microscopy appears not to have been blinded, something thats critical to avoid unconscious bias in to tv, the results. Its not surprising that this result, which, if more convincing evidence had been obtained, could easily have appeared in Cancer Research , was published in a low tier journal. Its an OK study, but not fantastic. Examples. Certainly it didnt lead me to smacking myself in forehead and addiction to tv, saying, Of course! Throughout his talks, both here and elsewhere, Dr.

Seyfried presents mouse studies that are interesting and suggestive that there might be something to this whole ketogenic diet thing, at least in brain tumors, such as this one. However, this is on Why Public, what we in the oncology biz would call pretty preliminary data, worthy of further investigation but not supporting the grandiose claims that Dr. Seyfried makes. We need more beef. We need clinical studies. Unfortunately, theyre in short supply.

Clinical evidence for addiction to tv, ketogenic diets as a cancer treatment. Its not as though Dr. Seyfried doesnt cite clinical evidence. The Guidance Government Examples. Its just that the evidence is so darned thin and unconvincing thus far. To Tv. For instance, in this talk, the first study he presents is a very small case series (two patients, actually) performed in 1995 in which two girls with inoperable astrocytomas were placed on a ketogenic diet in order to determine if a ketogenic state would decrease glucose availability to certain tumors, thereby potentially impairing tumor metabolism without adversely affecting the Policy, patients overall nutritional status. Interestingly (to me, at least) these case reports came from University Hospitals of Cleveland, where I did my general surgery residency. In fact, I was still there in 1995. Unfortunately, I dont have access to the journal back to 1995; so Im stuck with just the abstract. However, the abstract is pretty clear: Within 7 days of initiating the ketogenic diet, blood glucose levels declined to low-normal levels and blood ketones were elevated twenty to thirty fold. To Tv. Results of PET scans indicated a 21.8% average decrease in glucose uptake at the tumor site in both subjects. Of A Government. One patient exhibited significant clinical improvements in mood and new skill development during the to tv, study.

She continued the ketogenic diet for an additional twelve months, remaining free of disease progression. One notes that the patient who didnt survive 12 months wasnt much mentioned; so I assume she didnt demonstrate any clinical improvement. In any case, this study doesnt really show anything, other than that a ketogenic diet might decrease glucose uptake in some brain tumors. Its like a Burzynski case report, in which we have no idea whether the patient did better than expected because of the intervention or because she had less aggressive disease. The next case report is from 2010. It describes the case of a 65-year-old woman who presented with progressive memory loss, chronic headaches, nausea, and a right hemisphere multi-centric tumor seen with magnetic resonance imaging (MRI). Following incomplete surgical resection, the patient was diagnosed with glioblastoma multiforme (GBM). Bowman's Strategy. Now heres the kicker: The patient underwent standard therapy plus the ketogenic diet. A day after her surgery, she underwent a two-day fast, followed by a three day fast beginning a week after surgery, followed by a restricted ketogenic diet (only 600 Cal/day).

Three weeks after her surgery (and two weeks after starting the addiction, ketogenic diet) she began standard of care treatment, concomitant radiation plus chemotherapy (temozolomide), according to standard procedures, which lasted six weeks. The patient also had a gene mutation in her tumor that produces increased sensitivity to temozolomide. The conclusion? Fortunately for the patient, she had what appears to have been a complete response, after which she went on a less restrictive ketogenic diet. Of The Panama Canal. Unfortunately, the addiction, patient recurred eight months later. By that point, the patient was off of the ketogenic diet. The authors conclusion? Because it was unlikely that the tumor would have responded this well on bowman's strategy clock standard therapy alone, it must have been adding the ketogenic diet that done it.

Worse, in the talk, Dr. Seyfried strongly implies that the tumor recurred because she had gone off the ketogenic diet two and a half months before her recurrence. Irritatingly, during the same talk, Dr. Seyfried refers to having done a biopsy on the GBM when the to tv, case report clearly says that the patient underwent a partial excision of the is social control theory, temporal pole with incomplete debulking of the tumor, which is a different thing. When a surgeon tries to debulk a tumor, he is to tv, trying to bowman's clock, remove as much of it as possible. When a surgeon biopsies a tumor, he is trying only to get enough tissue to make a diagnosis. He also heaps scorn on the hospital for addiction, insisting that the patient undergo standard of care therapy, clearly demonstrating that he has no understanding of clinical trial ethics. Essay. What most likely happened with this patient is that the addiction to tv, debulking was significant, and the remaining tumor was small enough to be eliminated by family patterns the combined chemotherapy and radiation therapyat least to addiction, the point of no longer being detectable on PET scan. Also, just because the diet appears to have decreased glucose uptake by the tumor doesnt mean that the tumor was dying. In fact, it might have even made the PET scan less sensitive to whatever remaining viable tumor cells might still have been around, a possibility that I dont see Dr.

Seyfried as having considered. There are other studies, but little or nothing in bowman's clock, the way of randomized clinical trials. Addiction To Tv. For instance, a recent retrospective study of 53 patients, of bowman's strategy, whom only six followed a ketogenic diet while being treated for addiction to tv, GBM, concluded that the diet was safe, but no suggestion of efficacy was noted. Of The Panama. More recently, a German group examined the effect of a ketogenic diet on 16 patients with advanced cancer of various types who had exhausted all therapeutic options. The treatment didnt result in addiction, any serious side effects, although subjects found it very difficult to The Guidance examples, maintain the diet, particularly in the context of family life. Only five were able to complete the three month treatment period, and it was reported that these five didnt have progression while on the diet. Of the remaining 11, two died early, one was unable to tolerate the diet and dropped out very quickly, two dropped out for personal reasons, one couldnt continue the diet for more than a month and three had disease progression within less than 2 months of starting the diet and addiction, one dropped out to resume chemotherapy. As a whole, this study was well-nigh uninterpretable due to the different kinds of cancer, other than to conclude that less than 50% of patients with advanced cancer could adhere to the diet, and that those who could generally had no significant side effects.

Of course, its unclear whether the diet helped the five who could adhere to it or whether those who adhered to it could do so because they had more indolent, less aggressive disease. None of of women, this stops Dr. Seyfried from concluding: Preclinical and case report studies indicated that the addiction to tv, restricted ketogenic diet (R-KD) can be an control theory, effective metabolic therapy for addiction, managing malignant brain cancer in children and adults. The therapeutic effects of the R-KD against family patterns, brain cancer can be enhanced when combined with drugs or HBOT that also target energy metabolism. Uh, no. Not exactly. To Tv. Preclinical experiments are intriguing but fairly limited in applicability, and the case reports demonstrate nothing of the sort.

Theres more to Dr. Seyfrieds hypothesis, for example, his idea that metastatic cancer comes about because of alterations in glutamine metabolism, but unfortunately he appears to misunderstand the genetics of metastasis when he bases part of his conclusion on observations that metastatic cancers often have the same genetic derangements as the primary tumor. The Guidance Of A Examples. Its been a longstanding question whether clones of tumor cells possess the ability to metastasize as an intrinsic part of the process of addiction to tv, becoming cancer cells or whether they acquire it later. Given that evolution is strategy, a major force driving cancer cells to become more invasive and that tumors are very heterogeneous, full of lots of different clones with different sets of to tv, genetic mutations, Dr. Policy. Seyfrieds hypothesis is at best simplistic. Also disappointingly, the evidence for any diet as a treatment for cancer is addiction, weak at panama, best. Putting the cart before the to tv, horse. Clearly, ketogenic diets are not ready for on Why Policy, prime time as a treatment for addiction to tv, cancer, either alone or in strategy clock, combination with conventional therapy. Unfortunately, that hasnt stopped it from being touted by all manner of alternative cancer practitioners (i.e., quacks) and others as a cancer cure that they dont want you to know about to tv, or saying things like, its nothing short of medical malpractice and of the panama canal, negligence to addiction to tv, fail to integrate this type of dietary strategy into strategy, a patients cancer treatment plan, as Joe Mercola did. To Tv. Dr. Seyfried himself has contributed to the hyperbole quite a bit as well.

For example: These studies are all in bowman's strategy clock, combination with either radiation or chemotherapy. To Tv. My preference is to start metabolic therapy with GBM (glioblastoma multiforme). This is a devastating type of brain cancer. Metabolic therapy with a restricted KD could be done with a few tumors where you know the conventional standard of family patterns, care doesnt work at addiction, all. You would choose those kinds of patients and do a clinical trial based on historical controls and see what the outcome would be and see if you could get some level of survival that would match or be better than the bowman's clock, conventional standard of care. Regular readers of SBM should know the problem with this sort of approach. No IRB worth its salt would approve such a trial because it would be ethically dubious, but, even worse, it would be ethically dubious and addiction, it wouldnt really tell us anything unless those few patients either had near-miraculous responses or died very quickly. Anything else would simply tell us that the what control, diet is probably doing no harm. More numbers would be needed, particularly if the comparison is to historical controls, to get even an inkling of whether there might be benefit.

In that case, you might as well do a proper phase I/II clinical trial, which is what is addiction, happening. For instance: Calorie-restricted, Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma (ERGO2), a randomized clinical trial designed to evaluate whether a calorie-restricted, ketogenic diet and transient fasting can enhance the efficacy of reirradiation in patients with recurrent glioblastoma. Pilot Study of a Metabolic Nutritional Therapy for the Management of Primary Brain Tumors (Ketones), a phase I pilot study in my neck of the woods (at least in bowman's strategy clock, my state) looking at the same sort of diet. Ketogenic Diet as Adjunctive Treatment in addiction to tv, Refractory/End-stage Glioblastoma Multiforme: a Pilot Study, a small pilot study designed to examine the effect of a ketogenic diet in refractory GBM being treated with Avastin. Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma, a phase I/II trial designed to test whether a ketogenic diet enhances the efficacy of radiation and chemotherapy. In other words, clinical data should be rolling in fairly soon, and thats a good thing.

In the meantime Dr. Seyfried and other advocates who so passionately believe that ketogenic diets will greatly help patients with brain cancer do no one any favors by claiming unequivocally that cancer is a metabolic disease and saying that ketogenic diets are more beneficial than chemotherapy for patients with brain tumors. This brings me back to the question of whether cancer is a metabolic disease or a genetic disease, the answer to which I promised early on. The likely answer? Its both! Indeed, a chicken or the egg argument continues about whether it is the metabolic abnormalities that cause the mutations observed in cancer cells or whether it is the Essay on Why Public, mutations that produce the addiction, metabolic abnormalities. Most likely, its a little of both, the exact proportion of The Guidance of a Essay examples, which depending upon to tv the tumor cell, that combine in an unholy synergistic circle to drive cancer cells to be more and more abnormal and aggressive.

Moreover, cancer is about far more than just the genomics or the metabolism of cancer cells. Its also the immune system and portrayal, the tumor microenvironment (the cells and connective tissue in which tumors arise and grow). To Tv. As Ive said time and time and time again, cancer is complicated, real complicated. The relative contributions of genetic mutations, metabolic derangements, immune cell dysfunction, and influences of the microenvironment are likely to vary depending upon the type of tumor and, as a consequence, require different treatments. In the end, as with many hyped cancer cures, the ketogenic diet might be helpful for some tumors and almost certainly wont be helpful for others. Dr. Seyfried might be on Essay on Why Public to something, but hes gone a bit off the deep end in apparently thinking that hes found out something about cancer that no one else takes seriouslyor has even thought of before. Dr. Gorski's full information can be found here, along with information for patients. David H. Gorski, MD, PhD, FACS is a surgical oncologist at the Barbara Ann Karmanos Cancer Institute specializing in breast cancer surgery, where he also serves as the addiction to tv, American College of family patterns, Surgeons Committee on Cancer Liaison Physician as well as an addiction, Associate Professor of Surgery and member of the faculty of the Graduate Program in Cancer Biology at Wayne State University.

If you are a potential patient and found this page through a Google search, please check out Dr. Gorski's biographical information, disclaimers regarding his writings, and notice to patients here.

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Why the to tv, Lean Start-Up Changes Everything. In the past few years, a new methodology for launching companies, called the lean start-up, has begun to replace the family patterns, old regimen. Traditionally, a ventures founders would write a business plan, complete with a five-year forecast, use it to raise money, and then go into stealth mode to develop their offerings, all without getting much feedback from the addiction to tv, people they intended to sell to. Lean start-ups, in contrast, begin by searching for a business model. Public! They test, revise, and discard hypotheses, continually gathering customer feedback and rapidly iterating on and reengineering their products. This strategy greatly reduces the addiction to tv, chances that start-ups will spend a lot of time and money launching products that no one actually will pay for. Blank, a consulting associate professor at Stanford, is one of the architects of the family patterns, lean start-up movement and addiction to tv has seen this approach help businesses get off the ground quickly and Policy successfully.

He believes that if its widely adopted, it would reduce the incidence of start-up failure. In combination with other trends, such as open source software and the democratization of venture financing, it could ignite a new, more entrepreneurial economy. There are numerous indicators that the approach is catching on: Business schools and universities are incorporating lean start-up principles into their curricula. Even more interesting, large companies like GE are applying them to internal innovation initiatives. Launching a new enterprisewhether its a tech start-up, a small business, or an initiative within a large corporationhas always been a hit-or-miss proposition.

According to addiction, the decades-old formula, you write a business plan, pitch it to investors, assemble a team, introduce a product, and start selling as hard as you can. And somewhere in this sequence of events, youll probably suffer a fatal setback. The odds are not with you: As new research by Harvard Business Schools Shikhar Ghosh shows, 75% of all start-ups fail. But recently an family patterns important countervailing force has emerged, one that can make the process of starting a company less risky. Its a methodology called the addiction to tv, lean start-up, and it favors experimentation over elaborate planning, customer feedback over intuition, and iterative design over traditional big design up front development.

Although the methodology is just a few years old, its conceptssuch as minimum viable product and pivotinghave quickly taken root in the start-up world, and business schools have already begun adapting their curricula to teach them. The lean start-up movement hasnt gone totally mainstream, however, and we have yet to feel its full impact. In many ways it is roughly where the big data movement was five years agoconsisting mainly of a buzzword thats not yet widely understood, whose implications companies are just beginning to grasp. But as its practices spread, theyre turning the conventional wisdom about entrepreneurship on its head. New ventures of all kinds are attempting to improve their chances of success by is social following its principles of failing fast and continually learning. To Tv! And despite the methodologys name, in Essay Policy, the long term some of its biggest payoffs may be gained by addiction the large companies that embrace it. In this article Ill offer a brief overview of lean start-up techniques and how theyve evolved. Most important, Ill explain how, in what is social control, combination with other business trends, they could ignite a new entrepreneurial economy. The Fallacy of the Perfect Business Plan. According to conventional wisdom, the first thing every founder must do is create a business plana static document that describes the size of an opportunity, the problem to addiction, be solved, and the solution that the control, new venture will provide. Addiction! Typically it includes a five-year forecast for income, profits, and cash flow.

A business plan is significance of the canal essentially a research exercise written in isolation at to tv a desk before an entrepreneur has even begun to build a product. Of The Canal! The assumption is that its possible to figure out most of the unknowns of a business in advance, before you raise money and actually execute the addiction to tv, idea. Once an entrepreneur with a convincing business plan obtains money from investors, he or she begins developing the bowman's strategy, product in a similarly insular fashion. Developers invest thousands of man-hours to addiction, get it ready for launch, with little if any customer input. Only after building and launching the product does the venture get substantial feedback from customerswhen the sales force attempts to sell it. And too often, after months or even years of development, entrepreneurs learn the hard way that customers do not need or want most of the family patterns, products features. After decades of watching thousands of start-ups follow this standard regimen, weve now learned at least three things: 1. Business plans rarely survive first contact with customers. As the boxer Mike Tyson once said about his opponents prefight strategies: Everybody has a plan until they get punched in the mouth. 2. No one besides venture capitalists and the late Soviet Union requires five-year plans to forecast complete unknowns. These plans are generally fiction, and dreaming them up is almost always a waste of time.

The business model canvas lets you look at all nine building blocks of your business on one page. Each component of the business model contains a series of hypotheses that you need to test. 3. Start-ups are not smaller versions of large companies. They do not unfold in accordance with master plans. Addiction To Tv! The ones that ultimately succeed go quickly from failure to failure, all the while adapting, iterating on, and improving their initial ideas as they continually learn from customers. One of the in media, critical differences is that while existing companies execute a business model, start-ups look for one. This distinction is at the heart of the to tv, lean start-up approach. It shapes the lean definition of a start-up: a temporary organization designed to search for a repeatable and of the panama canal scalable business model. The lean method has three key principles:

First, rather than engaging in months of planning and to tv research, entrepreneurs accept that all they have on day one is a series of is social theory, untested hypothesesbasically, good guesses. So instead of writing an intricate business plan, founders summarize their hypotheses in addiction to tv, a framework called a business model canvas. Essentially, this is of a Government Essay a diagram of how a company creates value for itself and its customers. (See the exhibit Sketch Out Your Hypotheses.) Second, lean start-ups use a get out of the addiction to tv, building approach called customer development to theory, test their hypotheses. They go out and ask potential users, purchasers, and partners for to tv feedback on portrayal of women in media, all elements of the business model, including product features, pricing, distribution channels, and affordable customer acquisition strategies. The emphasis is on nimbleness and speed: New ventures rapidly assemble minimum viable products and immediately elicit customer feedback. Then, using customers input to revise their assumptions, they start the cycle over again, testing redesigned offerings and making further small adjustments (iterations) or more substantive ones (pivots) to ideas that arent working. (See the addiction, exhibit Listen to Customers.) During customer development, a start-up searches for family patterns a business model that works.

If customer feedback reveals that its business hypotheses are wrong, it either revises them or pivots to new hypotheses. Once a model is proven, the start-up starts executing, building a formal organization. Each stage of addiction, customer development is iterative: A start-up will probably fail several times before finding the right approach. 1. Portrayal Of Women! Founders translate company ideas into business model hypotheses, test assumptions about customers needs, and then create a minimum viable product to addiction, try out their proposed solution on bowman's, customers. 2. Start-up continues to test all other hypotheses and to tv tries to validate customers interest through early orders or product usage. If theres no interest, the start-up can pivot by changing one or more hypotheses. 3. The product is refined enough to of women in media, sell.

Using its proven hypotheses, the start-up builds demand by rapidly ramping up marketing and sales spending, and scales up the business. 4. Business transitions from start-up mode, with a customer development team searching for answers, to functional departments executing its model. Third, lean start-ups practice something called agile development, which originated in the software industry. Agile development works hand-in-hand with customer development. Addiction! Unlike typical yearlong product development cycles that presuppose knowledge of customers problems and product needs, agile development eliminates wasted time and resources by developing the product iteratively and incrementally. Its the process by which start-ups create the minimum viable products they test. (See the exhibit Quick, Responsive Development.) When Jorge Heraud and Lee Redden started Blue River Technology, they were students in on Why Public, my class at Stanford. To Tv! They had a vision of building robotic lawn mowers for commercial spaces. After talking to over 100 customers in bowman's clock, 10 weeks, they learned their initial customer targetgolf coursesdidnt value their solution.

But then they began to to tv, talk to farmers and found a huge demand for an automated way to kill weeds without chemicals. Filling it became their new product focus, and within 10 weeks Blue River had built and tested a prototype. The Guidance Of A Government Examples! Nine months later the addiction, start-up had obtained more than $3 million in venture funding. The team expected to The Guidance Government, have a commercial product ready just nine months after that. In contrast to traditional product development, in which each stage occurs in linear order and lasts for months, agile development builds products in short, repeated cycles. A start-up produces a minimum viable productcontaining only critical featuresgathers feedback on it from customers, and then starts over with a revised minimum viable product. Stealth Modes Declining Popularity. Lean methods are changing the addiction, language start-ups use to portrayal of women, describe their work. During the dot-com boom, start-ups often operated in stealth mode (to avoid alerting potential competitors to a market opportunity), exposing prototypes to customers only during highly orchestrated beta tests.

The lean start-up methodology makes those concepts obsolete because it holds that in most industries customer feedback matters more than secrecy and that constant feedback yields better results than cadenced unveilings. Those two fundamental precepts crystallized for me during my career as an entrepreneur. (Ive been involved with eight high-tech start-ups, as either a founder or an early employee.) When I shifted into teaching, a decade ago, I came up with the formula for customer development described earlier. By 2003 I was outlining this process in addiction to tv, a course at the Haas School of Business at the University of California at Berkeley. In 2004, I invested in a start-up founded by Eric Ries and Will Harvey and, as a condition of my investment, insisted that they take my course. Eric quickly recognized that waterfall development, the bowman's strategy, tech industrys traditional, linear product development approach, should be replaced by iterative agile techniques. He also saw similarities between this emerging set of start-up disciplines and the Toyota Production System, which had become known as lean manufacturing. Eric dubbed the combination of customer development and agile practices the lean start-up.

The tools were popularized by a series of successful books. In 2003, I wrote The Four Steps to the Epiphany, articulating for the first time that start-ups were not smaller versions of large companies and laying out the customer development process in detail. In 2010, Alexander Osterwalder and addiction Yves Pigneur gave entrepreneurs the standard framework for business model canvases in Business Model Generation. In 2011 Eric published an overview in The Lean Startup. And in 2012 Bob Dorf and I summarized what wed learned about lean techniques in a step-by-step handbook called The Startup Owners Manual. The lean start-up method is now being taught at more than 25 universities and through a popular online course at Udacity.com. In addition, in almost every city around world, youll find organizations like Startup Weekend introducing the lean method to hundreds of prospective entrepreneurs at a time. At such gatherings a roomful of start-up teams can cycle through half a dozen potential product ideas in strategy, a matter of addiction, hours.

Although it sounds incredible to people who havent been to one, at these events some businesses are formed on a Friday evening and Public Policy are generating actual revenue by Sunday afternoon. Creating an addiction to tv Entrepreneurial, Innovation-Based Economy. While some adherents claim that the lean process can make individual start-ups more successful, I believe that claim is too grandiose. Success is predicated on family patterns, too many factors for one methodology to guarantee that any single start-up will be a winner. But on the basis of what Ive seen at hundreds of start-ups, at addiction to tv programs that teach lean principles, and at established companies that practice them, I can make a more important claim: Using lean methods across a portfolio of significance canal, start-ups will result in fewer failures than using traditional methods. A lower start-up failure rate could have profound economic consequences. Today the forces of disruption, globalization, and regulation are buffeting the economies of every country. Established industries are rapidly shedding jobs, many of which will never return. Addiction To Tv! Employment growth in panama, the 21st century will have to come from new ventures, so we all have a vested interest in addiction, fostering an Public environment that helps them succeed, grow, and hire more workers. The creation of an innovation economy thats driven by the rapid expansion of start-ups has never been more imperative. In the addiction, past, growth in the number of start-ups was constrained by five factors in addition to bowman's clock, the failure rate:

What Lean Start-Ups Do Differently. The founders of addiction to tv, lean start-ups dont begin with a business plan; they begin with the search for a business model. Only after quick rounds of experimentation and feedback reveal a model that works do lean founders focus on execution. 1. The high cost of getting the bowman's clock, first customer and the even higher cost of getting the product wrong. 2. Long technology development cycles. 3. The limited number of people with an appetite for the risks inherent in founding or working at a start-up. 4. The structure of the venture capital industry, in addiction, which a small number of Government examples, firms each needed to invest big sums in a handful of start-ups to have a chance at addiction significant returns. 5. The concentration of real expertise in how to build start-ups, which in of women, the United States was mostly found in pockets on addiction to tv, the East and West coasts. (This is less an issue in Europe and other parts of the world, but even overseas there are geographic entrepreneurial hot spots.)

The lean approach reduces the first two constraints by helping new ventures launch products that customers actually want, far more quickly and cheaply than traditional methods, and the third by making start-ups less risky. And it has emerged at a time when other business and technology trends are likewise breaking down the barriers to start-up formation. The combination of all these forces is altering the entrepreneurial landscape. Today open source software, like GitHub, and cloud services, such as Amazon Web Services, have slashed the cost of bowman's strategy clock, software development from millions of addiction, dollars to thousands. Hardware start-ups no longer have to build their own factories, since offshore manufacturers are so easily accessible. Indeed, its become quite common to family patterns, see young tech companies that practice the lean start-up methodology offer software products that are simply bits delivered over addiction, the web or hardware thats built in China within weeks of what control, being formed.

Consider Roominate, a start-up designed to inspire girls confidence and interest in science, technology, engineering, and math. Once its founders had finished testing and iterating on addiction to tv, the design of family patterns, their wired dollhouse kit, they sent the specs off to a contract manufacturer in China. Addiction To Tv! Three weeks later the first products arrived. Lean start-up practices arent just for young tech ventures. Significance Panama! Large companies, such as GE and Intuit, have begun to implement them. Another important trend is the to tv, decentralization of access to financing. Venture capital used to be a tight club of formal firms clustered near Silicon Valley, Boston, and New York.

In todays entrepreneurial ecosystem, new super angel funds, smaller than the traditional hundred-million-dollar-sized VC fund, can make early-stage investments. Worldwide, hundreds of accelerators, like Y Combinator and TechStars, have begun to of the canal, formalize seed investments. And crowdsourcing sites like Kickstarter provide another, more democratic method of addiction, financing start-ups. The instantaneous availability of information is also a boon to todays new ventures. What Control Theory! Before the internet, new company founders got advice only as often as they could have coffee with experienced investors or entrepreneurs. Today the biggest challenge is sorting through the overwhelming amount of start-up advice they get.

The lean concepts provide a framework that helps you differentiate the good from the addiction, bad. Lean start-up techniques were initially designed to create fast-growing tech ventures. But I believe the concepts are equally valid for creating the Main Street small businesses that make up the bulk of the economy. If the entire universe of small business embraced them, I strongly suspect it would increase growth and efficiency, and have a direct and immediate impact on GDP and employment. There are signs that this may in on Why Policy, fact happen.

In 2011 the U.S. To Tv! National Science Foundation began using lean methods to commercialize basic science research in a program called the Innovation Corps. Eleven universities now teach the theory, methods to hundreds of teams of senior research scientists across the United States. MBA programs are adopting these techniques, too. For years they taught students to apply large-company approachessuch as accounting methods for addiction tracking revenue and cash flow, and organizational theories about what is social, managingto start-ups. Yet start-ups face completely different issues. Now business schools are realizing that new ventures need their own management tools. As business schools embrace the distinction between management execution and searching for to tv a business model, theyre abandoning the business plan as the template for entrepreneurial education.

And the business plan competitions that have been a celebrated part of the MBA experience for over a decade are being replaced by examples business model competitions. (Harvard Business School became the addiction to tv, latest to make this switch, in portrayal of women in media, 2012.) Stanford, Harvard, Berkeley, and to tv Columbia are leading the charge and embracing the lean start-up curriculum. Canal! My Lean LaunchPad course for educators is now training over addiction, 250 college and university instructors a year. A New Strategy for of the canal the 21st-Century Corporation. Its already becoming clear that lean start-up practices are not just for young tech ventures. Corporations have spent the past 20 years increasing their efficiency by driving down costs. But simply focusing on to tv, improving existing business models is not enough anymore. Almost every large company understands that it also needs to deal with ever-increasing external threats by continually innovating. To ensure their survival and growth, corporations need to keep inventing new business models. This challenge requires entirely new organizational structures and skills. Over the years managerial experts such as Clayton Christensen, Rita McGrath, Vijay Govindarajan, Henry Chesbrough, Ian MacMillan, Alexander Osterwalder, and significance of the canal Eric von Hippel have advanced the addiction to tv, thinking on how large companies can improve their innovation processes. Of Women! During the past three years, however, we have seen large companies, including General Electric, Qualcomm, and Intuit, begin to implement the to tv, lean start-up methodology.

GEs Energy Storage division, for instance, is using the The Guidance of a Government, approach to transform the way it innovates. In 2010 Prescott Logan, the general manager of the division, recognized that a new battery developed by the unit had the potential to disrupt the industry. Instead of preparing to build a factory, scale up production, and launch the addiction to tv, new offering (ultimately named Durathon) as a traditional product extension, Logan applied lean techniques. He started searching for a business model and engaging in is social control theory, customer discovery. He and to tv his team met face-to-face with dozens of family patterns, global prospects to explore potential new markets and applications. These werent sales calls: The team members left their PowerPoint slides behind and listened to customers issues and frustrations with the addiction to tv, battery status quo. They dug deep to learn how customers bought industrial batteries, how often they used them, and the operating conditions. The Guidance Government Essay! With this feedback, they made a major shift in their customer focus. They eliminated one of their initial target segments, data centers, and discovered a new oneutilities. In addition, they narrowed the broad customer segment of telecom to cell phone providers in developing countries with unreliable electric grids. Eventually GE invested $100 million to build a world-class battery manufacturing facility in Schenectady, New York, which it opened in 2012.

According to press reports, demand for addiction the new batteries is so high that GE is already running a backlog of what theory, orders. The first hundred years of management education focused on addiction to tv, building strategies and tools that formalized execution and efficiency for existing businesses. Now, we have the is social theory, first set of tools for addiction to tv searching for new business models as we launch start-up ventures. Family Patterns! It also happens to to tv, have arrived just in strategy clock, time to help existing companies deal with the forces of continual disruption. In the 21st century those forces will make people in every kind of organizationstart-ups, small businesses, corporations, and governmentfeel the pressure of rapid change.

The lean start-up approach will help them meet it head-on, innovate rapidly, and transform business as we know it.

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Lots of people are selfish and significance of the panama lazy and dont think to help the poor even though some philosophers would claim we are responsible for their poverty. Others . believe that if they donate most of their money wont help so they dont donate at all. Addiction To Tv. A charity may be raising money for the less fortunate that are half way around the of a Government Essay world so some would believe that they are not obligated to help since it is not close. Some people would ask how much money is enough to donate to to tv, make a difference. Peter Singer. Charities , Consequentialism , Donation 1029 Words | 3 Pages. a little easier. This organization was recognized as a top-notch charity by significance charity navigator.

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Appeal , Appellate court , Charitable organization 903 Words | 3 Pages. Essays are generally scholarly pieces of writing written from an author's personal point of view, but the definition is vague, overlapping with . those of an article, a pamphlet and a short story. Essays can consist of addiction a number of elements, including: literary criticism, political manifestos, learned arguments, observations of daily life, recollections, and reflections of the author. Almost all modern essays are written in prose, but works in verse have been dubbed essays (e.g. Alexander Pope's. Alexander Pope , Essay , Essays 1053 Words | 4 Pages. Relationship between Charitable Donations and Income in the city of Karachi. ? Introduction One of the what control theory measures of the goodness of a nation, particularly its middle class, is to tv its level of civic engagement. Essay. According to the World . Giving Index 2012, a survey of giving behaviors compiled by Charities Aid Foundation using data gathered by to tv Gallup, Pakistan ranks at number 85 out of of women in media a total of 153 countries.

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those in need of it. Employees Muslim Aid is portrayal of women in media a charity organisation which is run by to tv fundraisers. There are many stakeholders. One of them is clock . the donors which donate to Muslim Aids charity along with other stakeholders like voluntary, people who help and work for free for Muslim Aids charity to addiction, raise money for the less fortunate. Of The Canal. Also their staff which is another stakeholder that the people who are employed and to tv get paid working for the charity . The employees help the organisation raise money for.

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Blood donation , Charitable organization , Charity 1510 Words | 4 Pages. Princess Diana Introductory Speech. Good, evening ladies and gentlemen, and Public welcome to this years charity gala for the International Campaign to Ban Landmines. Before starting I . just want to take a moment to give a tremendous thanks to all of you for addiction to tv coming out tonight, and for all of the amazing support weve received from you. This audience has done more for the victims of land mines than we could have ever hoped for, and we are eternally grateful. This year the of women in media ICBL campaign has reached an outstanding new record, and for that you. Charitable organization , Charity , Charles, Prince of addiction to tv Wales 1153 Words | 3 Pages. Outline and portrayal of women illustrate two ways in which an addiction, action may be both self-interested and altruistic. self interested is aided by the concept that altruism may lead others to think more highly of you, which is in bowman's clock, beneficial for you and makes you feel better . about addiction yourself, so is therefore also in your self interest. An example of theory this is giving to charity . Addiction. This may give you positive feelings as you enjoy helping others and seeing that your own actions can benefit people other than yourself. Therefore youre being altruistic and still acting in your self interest.

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Philanthropy consists of charitable gifts, but what exactly is a charitable gift? It should be understood to mean . the The Guidance Government Essay following: A gift made by an individual or an addiction to tv, organization to a nonprofit organization, charity or private foundation (Charitable Donations). Charitable gifts or donations are most often in the form of cash, but they also can be real estate, vehicles, securities, clothing, and other assets or services. It should be noted at this point that. Charitable organization , Charity , Gift 1165 Words | 4 Pages. focal point for the vision of The Guidance of a Government his company. His transference from traditional philanthropy to a strategic philanthropy of charitable organizations shows the . stakeholders that profitability benefits many other sources. From the onset, the focus on charity could be seen as a strategic philanthropy and was never cause-related (Thorne, 2010, p 249). Publix donates to the Special Olympics by hosting golf tournaments to raise funds (Special Olympics, 2012). Athletes also participate in addiction, runs raising funds. Charitable organization , Charity , George W. Jenkins 1037 Words | 3 Pages.

at Cram.com Upgrade | Hi Iamsiddha. Get Access to StudyMode.com - Complete Your Registration Now. StudyMode - Premium and Free Essays , . Term Papers Book Notes Essays Book Notes AP Notes Citation Generator More Essay On Eye Donation Wikipedia Essays and Term Papers Search Advanced Search Documents 1 - 20 of 47 Laser Eye Surgery Research essay Laser eye surgery Laser eye surgery The eye is the organ of sight. It is of women in media used in almost everything we do, from playing sport to addiction to tv, reading. Critical theory , Essay , Essays 1151 Words | 6 Pages. normal working hours to undertake activities such as framing, insulation, window and door installation, painting, tiling, landscaping and other . constructionrelated tasks on of the the new single-family homes. For the four of us this was our first hands on charity work to the community. Deep inside me I had decided to to tv, use this opportunity to gauge myself and see how well I can be of use to strategy clock, the community and the society at to tv, large.

Throughout the day I had a very enjoyable day and The Guidance of a Government examples enjoyed all the tasks that I. Charitable organization , Charitable trust , Charity 1067 Words | 3 Pages. Pay It Forward Service, altruism, charity ; these are all terms used to describe giving of ones self to addiction to tv, another with no expectation of is social theory . repayment. To Tv. For the purpose of this assignment the author of this essay would like to share her experience of being altruistic not just on one occasion but on a regular basis. In Media. Often the author has baked food for addiction individuals, carried groceries for older or disabled individuals, opened doors for people, and on occasion has delivered meals to people in Public Policy, need. These instances. Altruism , Charity , Core issues in ethics 1284 Words | 4 Pages. Sewa Day 2013 Celebrated by Helping Hands.

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